Cucurbit[6]uril is an ultrasensitive129Xe NMR contrast agent
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چکیده
منابع مشابه
Gadolinium as a contrast agent for NMR.
Gadolinium chloride (GdCl3) was studied as a contrast agent for nuclear magnetic resonance. This rare-earth element dramatically alters proton resonance (paramagnetic moment = 10.8 Bohr magnetons). Acute toxicity was determined by intravenous injections in mice; mean lethal dose was 100-200 mg of GdCl3 . 6 H2O/kg. Changes in T1 of plasma, kidney, liver, and brain of mice and rats were measured ...
متن کاملCucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.
A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] bind...
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Chelation of the rare-earth element gadolinium (Gd) with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic gadolinium complex reduces hydrogen-proton relaxation times even in low concentrations (less than 0.01 mmol/L). The pharmacokinetic behavior of intravenously delivered Gd-DTPA is similar...
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Introduction: Gd (III) ion has been known to be the best metal ion in the periodic table that can be used as a T1 MRI contrast agent. Gadolinium have 7 unpaired electrons and these electrons can make magnetic area. No other metal ions possess unpaired electron more than this. CAs based on the element Gd are classified as “positive”, by opposition to “negative” CAs. Nowadays, G...
متن کاملHydrothermal Synthesis of an Ethiodol Based Ferrofluid as a Potential MRI Contrast Agent
In the present work, stable ferrofluids containing oleic acid capped magnetite nanoparticles were synthesized via low temperature hydrothermal method. The physical and chemical properties of the synthesized particles were studied using TEM, XRD, AFM, VSM and PCS techniques. Mean particles size of the samples was between 4.5 and 10 nanometers, depending on experimental conditions. Effect ...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2015
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc01826a